{"id":14397,"date":"2026-07-10T15:06:29","date_gmt":"2026-07-10T09:36:29","guid":{"rendered":"https:\/\/www.class24.study\/current-affairs\/?p=14397"},"modified":"2026-07-10T16:30:40","modified_gmt":"2026-07-10T11:00:40","slug":"world-first-once-weekly-insulin","status":"publish","type":"post","link":"https:\/\/www.class24.study\/current-affairs\/world-first-once-weekly-insulin\/","title":{"rendered":"World&#8217;s First Once-Weekly Insulin Launched in India: A Major Diabetes Breakthrough"},"content":{"rendered":"<p><span style=\"font-weight: 400\">World&#8217;s First Weekly Insulin Debuts: Novo Nordisk has introduced a new long-acting agent in diabetes management, Awiqli (Insulin Icodec)- The first once-weekly basal insulin globally- and is now available in India. The groundbreaking treatment could revolutionise diabetes care by reducing the need for insulin injections on a daily basis and increasing patient compliance. <\/span><\/p>\n<p><span style=\"font-weight: 400\">The innovation is set to cater for millions of patients and bolster India&#8217;s healthcare ecosystem, as India boasts one of the largest diabetic populations around the world. The launch is based on successful global clinical trials and regulatory approvals, making this an important development in medical science and current affairs.<\/span><\/p>\n<h2><span style=\"font-weight: 400\">Why in News?<\/span><\/h2>\n<p><span style=\"font-weight: 400\">Novo Nordisk expanded the availability of Awiqli (Insulin Icodec) in India, where it was approved, becoming one of the first country -located to launch globally for eligible adults with diabetes. The launch intends to simplify insulin therapy and improve treatment adherence by minimising the injection frequency from 365 injections yearly to only 52 per year.<\/span><\/p>\n<h2><span style=\"font-weight: 400\">Key Highlights of Once-Weekly Insulin<\/span><\/h2>\n<table>\n<tbody>\n<tr>\n<td><b>Particular<\/b><\/td>\n<td><b>Details<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">News<\/span><\/td>\n<td><span style=\"font-weight: 400\">World&#8217;s First Once-Weekly Insulin Launched in India<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">Medicine<\/span><\/td>\n<td><span style=\"font-weight: 400\">Awiqli<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">Generic Name<\/span><\/td>\n<td><span style=\"font-weight: 400\">Insulin Icodec<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">Developed By<\/span><\/td>\n<td><span style=\"font-weight: 400\">Novo Nordisk<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">Type<\/span><\/td>\n<td><span style=\"font-weight: 400\">Once-Weekly Basal Insulin<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">Launch<\/span><\/td>\n<td><span style=\"font-weight: 400\">July 2026<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">Injection Frequency<\/span><\/td>\n<td><span style=\"font-weight: 400\">Once Every Week<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">Major Benefit<\/span><\/td>\n<td><span style=\"font-weight: 400\">Replaces Daily Basal Insulin<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">Clinical Programme<\/span><\/td>\n<td><span style=\"font-weight: 400\">ONWARDS Phase III Trials<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">Significance<\/span><\/td>\n<td><span style=\"font-weight: 400\">First Weekly Insulin Therapy in the World<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span style=\"font-weight: 400\">What is Awiqli (Insulin Icodec)?<\/span><\/h2>\n<p><span style=\"font-weight: 400\">Awiqli is a long-acting<\/span><b> &#8216;ultra&#8217; basal insulin<\/b><span style=\"font-weight: 400\"> that aims to manage glycaemic control for an entire week with just one shot. It is an insulin analogue, Insulin Icodec, that was developed to release itself over a week.<\/span><\/p>\n<p><span style=\"font-weight: 400\">Awiqli has the benefit of decreasing the injection frequency, unlike conventional basal insulin, which is given daily, whilst maintaining glycaemic control. The drug is meant for long-term management of the condition under medical supervision and is seen as one of the great new advances in insulin therapy over the last several decades.<\/span><\/p>\n<h2><span style=\"font-weight: 400\">Why is Once-Weekly Insulin a Major Breakthrough?<\/span><\/h2>\n<p><span style=\"font-weight: 400\">The Awiqli (Insulin Icodec) is a major step forward as it completely transforms basal insulin delivery. Legacy requires daily injections for patients with diabetes needing basal insulin, which results in treatment fatigue, including missed doses and poor compliance. A once-weekly insulin reduces injection burden by up to almost 86%, simplifies diabetes management while achieving effective blood glucose control. <\/span><\/p>\n<p><span style=\"font-weight: 400\">Novo Nordisk stated that the ONWARDS Phase III clinical trial programme for the medicine showed efficacy and safety in eligible patients, with glycaemic control similar to daily basal insulin. This breakthrough may encourage better patient compliance, improve quality of life and lead to a reduction in diabetes-associated complications due to non-compliance, the issue of which is especially relevant in countries facing an increasing burden of diabetes like India, thereby improving long-term health outcomes.<\/span><\/p>\n<h2><span style=\"font-weight: 400\">How Does Insulin Icodec Work?<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Novo Nordisk has developed insulin Icodec, a once-weekly basal insulin analogue.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Its single injection is designed for a week of sustained glucose-lowering effects.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Insulin binds tightly, but reversibly, to circulating serum albumin, resulting in slow release over seven days.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">It keeps basal insulin levels constant, regulating blood glucose levels in between meals and while you sleep.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Patients self-inject once every 7 days on the same day of the week as instructed by a healthcare provider.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">This long-lasting effect is presumably due to the design of its molecules, as it has a half-life of about one week.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Its efficacy and safety compared to daily basal insulin were proven in the ONWARDS Phase III clinical trial programme.<\/span><\/li>\n<li style=\"font-weight: 400\"><span style=\"font-weight: 400\">Novo Nordisk has developed Insulin Icodec with the aim of reducing treatment burden and improving adherence to insulin therapy whilst maintaining effective glycaemic control.<\/span><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400\">Previous Year Questions (PYQs) on Insulin &amp; Diabetes<\/span><\/h2>\n<table>\n<tbody>\n<tr>\n<td><b>Exam<\/b><\/td>\n<td><b>Year<\/b><\/td>\n<td><b>Question<\/b><\/td>\n<td><b>Options<\/b><\/td>\n<td><b>Correct Answer<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">UPSC Prelims<\/span><\/td>\n<td><span style=\"font-weight: 400\">2023<\/span><\/td>\n<td><span style=\"font-weight: 400\">Diabetes mellitus is primarily caused by the deficiency or improper utilisation of which hormone?<\/span><\/td>\n<td><span style=\"font-weight: 400\">(A) Thyroxine (B) <\/span><b>Insulin<\/b><span style=\"font-weight: 400\"> (C) Adrenaline (D) Cortisol<\/span><\/td>\n<td><b>(B) Insulin<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">SSC CGL<\/span><\/td>\n<td><span style=\"font-weight: 400\">2022<\/span><\/td>\n<td><span style=\"font-weight: 400\">Which organ of the human body produces insulin?<\/span><\/td>\n<td><span style=\"font-weight: 400\">(A) Liver (B) Kidney (C) <\/span><b>Pancreas<\/b><span style=\"font-weight: 400\"> (D) Spleen<\/span><\/td>\n<td><b>(C) Pancreas<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">SSC CHSL<\/span><\/td>\n<td><span style=\"font-weight: 400\">2021<\/span><\/td>\n<td><span style=\"font-weight: 400\">Insulin is secreted by which cells of the pancreas?<\/span><\/td>\n<td><span style=\"font-weight: 400\">(A) Alpha Cells (B) <\/span><b>Beta Cells<\/b><span style=\"font-weight: 400\"> (C) Delta Cells (D) Acinar Cells<\/span><\/td>\n<td><b>(B) Beta Cells<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">CDS<\/span><\/td>\n<td><span style=\"font-weight: 400\">2020<\/span><\/td>\n<td><span style=\"font-weight: 400\">Which hormone is responsible for lowering blood glucose levels in the human body?<\/span><\/td>\n<td><span style=\"font-weight: 400\">(A) Glucagon (B) Thyroxine (C) <\/span><b>Insulin<\/b><span style=\"font-weight: 400\"> (D) Adrenaline<\/span><\/td>\n<td><b>(C) Insulin<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">NDA<\/span><\/td>\n<td><span style=\"font-weight: 400\">2019<\/span><\/td>\n<td><span style=\"font-weight: 400\">The Islets of Langerhans are present in which organ?<\/span><\/td>\n<td><span style=\"font-weight: 400\">(A) Liver (B) <\/span><b>Pancreas<\/b><span style=\"font-weight: 400\"> (C) Kidney (D) Gall Bladder<\/span><\/td>\n<td><b>(B) Pancreas<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">RRB NTPC<\/span><\/td>\n<td><span style=\"font-weight: 400\">2021<\/span><\/td>\n<td><span style=\"font-weight: 400\">Diabetes mellitus occurs mainly due to insufficient secretion of which hormone?<\/span><\/td>\n<td><span style=\"font-weight: 400\">(A) Estrogen (B) Testosterone (C) <\/span><b>Insulin<\/b><span style=\"font-weight: 400\"> (D) Progesterone<\/span><\/td>\n<td><b>(C) Insulin<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">SSC GD<\/span><\/td>\n<td><span style=\"font-weight: 400\">2023<\/span><\/td>\n<td><span style=\"font-weight: 400\">Which hormone regulates the level of glucose in the blood?<\/span><\/td>\n<td><span style=\"font-weight: 400\">(A) Growth Hormone (B) Thyroxine (C) <\/span><b>Insulin<\/b><span style=\"font-weight: 400\"> (D) Melatonin<\/span><\/td>\n<td><b>(C) Insulin<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">State PCS<\/span><\/td>\n<td><span style=\"font-weight: 400\">2022<\/span><\/td>\n<td><span style=\"font-weight: 400\">Which cells of the pancreas produce insulin?<\/span><\/td>\n<td><span style=\"font-weight: 400\">(A) Alpha Cells (B) Gamma Cells (C) <\/span><b>Beta Cells<\/b><span style=\"font-weight: 400\"> (D) PP Cells<\/span><\/td>\n<td><b>(C) Beta Cells<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">UPSC CAPF<\/span><\/td>\n<td><span style=\"font-weight: 400\">2021<\/span><\/td>\n<td><span style=\"font-weight: 400\">Which disease is commonly treated using insulin therapy?<\/span><\/td>\n<td><span style=\"font-weight: 400\">(A) Hypertension (B) Asthma (C) <\/span><b>Diabetes Mellitus<\/b><span style=\"font-weight: 400\"> (D) Tuberculosis<\/span><\/td>\n<td><b>(C) Diabetes Mellitus<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400\">SSC MTS<\/span><\/td>\n<td><span style=\"font-weight: 400\">2020<\/span><\/td>\n<td><span style=\"font-weight: 400\">Insulin was discovered by which scientists?<\/span><\/td>\n<td><span style=\"font-weight: 400\">(A) Watson &amp; Crick (B) <\/span><b>Frederick Banting &amp; Charles Best<\/b><span style=\"font-weight: 400\"> (C) Louis Pasteur (D) Edward Jenner<\/span><\/td>\n<td><b>(B) Frederick Banting &amp; Charles Best<\/b><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: center\"><a href=\"https:\/\/www.class24.study\/current-affairs\/world-bank-income-classification\/\" target=\"_blank\" rel=\"noopener\">World Bank Income Classification 2026<\/a><\/p>\n<h2><span style=\"font-weight: 400\">Conclusion on World&#8217;s First Once-Weekly Basal Insulin<\/span><\/h2>\n<p><span style=\"font-weight: 400\">Awiqli (Insulin Icodec) is the world&#8217;s first once-weekly basal insulin, launched in India as a revolutionary step towards diabetes treatment. As diabetes rapidly rises, these innovations could improve medication adherence, simplify insulin therapy and ultimately lead to better patient outcomes. Awiqli confirms worldwide clinical evidence supporting the expanding role of medical innovation in treating chronic diseases.<\/span><\/p>\n<h2><span style=\"font-weight: 400\">World&#8217;s First Weekly Insulin Debuts in India (FAQs)<\/span><\/h2>\n<div class=\"cfaq-wrapper\" data-multiple=\"0\"><div class=\"cfaq-item cfaq-open\"><button class=\"cfaq-question\" aria-expanded=\"true\"><span class=\"cfaq-question-text\">1. Which is the world&#039;s first once-weekly insulin?<\/span><span class=\"cfaq-icon\"><\/span><\/button><div class=\"cfaq-answer\"><div class=\"cfaq-answer-inner\"><div><span style=\"font-size: 12.35px\">Awiqli (Insulin Icodec), developed by Novo Nordisk, is the world's first once-weekly basal insulin.<\/span><\/div><\/div><\/div><\/div><div class=\"cfaq-item\"><button class=\"cfaq-question\" aria-expanded=\"false\"><span class=\"cfaq-question-text\">2. What is Insulin Icodec?<\/span><span class=\"cfaq-icon\"><\/span><\/button><div class=\"cfaq-answer\" hidden><div class=\"cfaq-answer-inner\"><div><span style=\"font-size: 12.35px\">Insulin Icodec is an ultra-long-acting basal insulin analogue designed to control blood sugar with one injection every seven days.<\/span><\/div><\/div><\/div><\/div><div class=\"cfaq-item\"><button class=\"cfaq-question\" aria-expanded=\"false\"><span class=\"cfaq-question-text\">3. Who launched Awiqli in India?<\/span><span class=\"cfaq-icon\"><\/span><\/button><div class=\"cfaq-answer\" hidden><div class=\"cfaq-answer-inner\"><span style=\"font-size: 12.35px\">Novo Nordisk launched Awiqli in India in July 2026.<\/span><\/div><\/div><\/div><div class=\"cfaq-item\"><button class=\"cfaq-question\" aria-expanded=\"false\"><span class=\"cfaq-question-text\">4. What is the biggest advantage of once-weekly insulin?<\/span><span class=\"cfaq-icon\"><\/span><\/button><div class=\"cfaq-answer\" hidden><div class=\"cfaq-answer-inner\"><div><span style=\"font-size: 12.35px\">It reduces insulin injections from 365 per year to only 52 annually, improving treatment adherence and convenience.<\/span><\/div><\/div><\/div><\/div><div class=\"cfaq-item\"><button class=\"cfaq-question\" aria-expanded=\"false\"><span class=\"cfaq-question-text\">5. Which clinical trial supported the approval of Awiqli?<\/span><span class=\"cfaq-icon\"><\/span><\/button><div class=\"cfaq-answer\" hidden><div class=\"cfaq-answer-inner\"><div><span style=\"font-size: 12.35px\">The ONWARDS Phase III Clinical Trial Programme supported the approval of Awiqli.<\/span><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>World&#8217;s First Weekly Insulin Debuts: Novo Nordisk has introduced a new long-acting agent in diabetes management, Awiqli (Insulin Icodec)- The first once-weekly basal insulin globally- and is now available in India. The groundbreaking treatment could revolutionise diabetes care by reducing the need for insulin injections on a daily basis and increasing patient compliance. The innovation [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":14398,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[21],"tags":[],"class_list":["post-14397","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-the-hindu-editorial"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.class24.study\/current-affairs\/wp-json\/wp\/v2\/posts\/14397","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.class24.study\/current-affairs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.class24.study\/current-affairs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.class24.study\/current-affairs\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.class24.study\/current-affairs\/wp-json\/wp\/v2\/comments?post=14397"}],"version-history":[{"count":3,"href":"https:\/\/www.class24.study\/current-affairs\/wp-json\/wp\/v2\/posts\/14397\/revisions"}],"predecessor-version":[{"id":14404,"href":"https:\/\/www.class24.study\/current-affairs\/wp-json\/wp\/v2\/posts\/14397\/revisions\/14404"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.class24.study\/current-affairs\/wp-json\/wp\/v2\/media\/14398"}],"wp:attachment":[{"href":"https:\/\/www.class24.study\/current-affairs\/wp-json\/wp\/v2\/media?parent=14397"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.class24.study\/current-affairs\/wp-json\/wp\/v2\/categories?post=14397"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.class24.study\/current-affairs\/wp-json\/wp\/v2\/tags?post=14397"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}